Cialis/Tadalafil: Solutions for ED, BPH & PAH

$80.00

Tadalafil is a medication phosphodiesterase 5 (PDE5) inhibitors used to treat erectile dysfunction(ED), benign prostatic hyperplasia(BPH), and pulmonary arterial hypertension(PAH). It is also known as Cialis powder and is used in the production of various medications for oral consumption. Tadalafil onset is typically within half an hour and the duration is up to 36 hours.

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Description

Mechanism of Action

Tadalafil inhibits the PDE5 enzyme, which is responsible for breaking down cyclic guanosine monophosphate (cGMP). By blocking PDE5, tadalafil increases cGMP levels, leading to smooth muscle relaxation and vasodilation in the corpus cavernosum of the penis, facilitating an erection when sexually stimulated.

Benefits of Tadalafil

✅Erectile Dysfunction (ED)
Tadalafil powder is formulated into tablets (e.g., Cialis) for oral use.
Known as the “weekend pill” due to its long duration of action (up to 36 hours).
✅Benign Prostatic Hyperplasia (BPH)
Helps relieve urinary symptoms by relaxing smooth muscles in the prostate and bladder.
✅Pulmonary Arterial Hypertension (PAH)
To improve exercise capacity by dilating pulmonary blood vessels.

Formulation and Solubility

✦Appearance: White to off-white crystalline powder.
✦Solubility: Poorly water-soluble; often processed into solid dispersions, nanocomposites, or microspheres to enhance bioavailability.
✦Common Excipients: Polymers like Kollidon® VA 64 or K12 are used to improve dissolution rates.

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