Viagra/Sildenafil: PDE5 Inhibitor for ED, PAH & BPH

Mechanism of Action

Sildenafil works by inhibiting the PDE5 enzyme, which is responsible for breaking down cyclic guanosine monophosphate (cGMP). By blocking PDE5, sildenafil increases cGMP levels, leading to smooth muscle relaxation and vasodilation in the corpus cavernosum of the penis, which helps achieve and maintain an erection during sexual stimulation.

Benefits of Sildenafil

✅Erectile Dysfunction (ED)
✦Sildenafil powder is formulated into tablets (e.g., Viagra) to treat ED by increasing blood flow to the penis.
✅Pulmonary Arterial Hypertension (PAH)
✦Used under the brand name Revatio to improve exercise capacity and delay clinical worsening in patients with PAH.
✅Benign Prostatic Hyperplasia (BPH)
✦May help relieve urinary symptoms by relaxing smooth muscles in the prostate and bladder.