Pharmaceutical-grade peptides & lab-use compounds available online.
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Skip to content Pharmaceutical-grade peptides & lab-use compounds available online.
Free US shipping for orders above $600
This product is intended solely for use as a research chemical in vitro and laboratory experimentation by licensed, qualified professionals.
ARA-290, also known as cibinetide or pHBSP (pyroglutamate helix B surface peptide), is an 11–amino acid peptide derived from the helix B region of erythropoietin (EPO). Unlike EPO, ARA-290 does not stimulate red blood cell production, focusing instead on tissue protection, anti-inflammation, and repair.
| 10mg*10vials | $70.00 | $80.00 |
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| Property | Details |
|---|---|
| Molecular Formula | C₅₁H₈₄N₁₆O₂₁ |
| Molecular Weight | 1257.31 g/mol |
| CAS Number | 1208243-50-8 |
| Appearance | White to off-white Powder |
| Composition | Lyophilized powder – requires reconstitution |
Innate Repair Receptor (IRR): ARA-290 selectively targets the IRR, a heteromeric complex composed of the erythropoietin receptor and the β-common (CD131) subunit. Activation of IRR triggers anti-inflammatory and tissue-repair pathways
TRPV1 Modulation: It also antagonizes TRPV1 (capsaicin receptor), which plays a key role in nociceptive pain signaling. This mechanism contributes to its analgesic (pain-relief) effects
Neuroprotection: ARA-290 has demonstrated neuroprotective properties in models of spinal cord injury, traumatic brain injury, and ischemic stroke, reducing neuronal damage and promoting functional recovery.
Cardioprotection: Studies have shown that ARA-290 can protect the heart from ischemia-reperfusion injury, reduce infarct size, and improve cardiac function in animal models of myocardial infarction.
Renal protection: ARA-290 has been found to attenuate renal injury and improve kidney function in preclinical models of acute kidney injury and chronic kidney disease.
Anti-inflammatory effects: The peptide exhibits potent anti-inflammatory properties, reducing the production of pro-inflammatory cytokines and promoting the resolution of inflammation in various tissues.
Wound healing: ARA-290 has been shown to accelerate wound healing and promote tissue repair in animal models of skin, corneal, and intestinal injuries.
Pain relief: Clinical studies have demonstrated that ARA-290 can effectively reduce neuropathic pain in patients with sarcoidosis and type 2 diabetes mellitus.
Research
Neural pain relief: ARA290 achieves regulation of neuro-immune inflammation through targeted binding to IRR, thereby exerting therapeutic effects on neuropathic pain.
Skin wound healing: ARA290 enhances the phagocytic function of macrophages, reducing the accumulation of apoptotic cells and the expression of pro-inflammatory factors in the wound, increasing the expression of anti-inflammatory factors and growth factors, promoting the resolution of wound inflammation and tissue repair, thereby accelerating skin wound healing.
Kidney protection: By mediating through EPOR and CD131, it inhibits the apoptosis of renal tubular epithelial cells in diabetic rats and exerts a protective effect on the kidneys.
Ischemia-reperfusion injury: Exerts protective effects on ischemia-reperfusion damage in the heart and brain through anti-apoptotic mechanisms.
To date, clinical studies report no erythropoietic effects at studied doses and few serious adverse events. That matters because the peptide was designed to avoid red blood cell stimulation while keeping tissue repair signals.
Common effects are generally mild and transient.
Injection site redness or minor discomfort.
Brief headache or fatigue reported by some participants.
Occasional transient nausea or lightheadedness.
All product is sold solely for scientific research purposes. Researchers are responsible for ensuring compliance with local regulations and institutional guidelines. Keep out of reach of children and unauthorized personnel.
1688pharmacy is more than just a trusted supplier of research peptides. We are committed to scientific advancement, dedicated to providing the highest quality pharmaceutical-grade compounds that empower researchers and clients to achieve their goals.
Our proprietary processes and meticulous sourcing of premium materials ensure that every peptide we offer meets the most stringent pharmaceutical standards with verified 99% purity.
Every peptide undergoes rigorous third-party laboratory testing using advanced techniques like HPLC, LC-MS, and NMR. Complete Certificates of Analysis available for transparency and verification.
We provide expedited worldwide shipping with reliable tracking and discreet packaging. Our dedicated customer support team assists with orders, storage guidelines, and product inquiries promptly.