Pharmaceutical-grade peptides & lab-use compounds available online.
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Skip to content Pharmaceutical-grade peptides & lab-use compounds available online.
Free US shipping for orders above $600
This product is intended solely for use as a research chemical in vitro and laboratory experimentation by licensed, qualified professionals.
FOXO4-DRI is a synthetic senolytic peptide designed to selectively eliminate senescent cells—often called “zombie cells”—which accumulate with age and contribute to tissue dysfunction, chronic inflammation, and age-related diseases.
| Specifications | Without Label Price | With Label Price |
|---|---|---|
| 10mg*10 vials | $380.00 | $390.00 |
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| Property | Details |
|---|---|
| Molecular Formula | C₂₂₈H₃₈₈N₈₆O₆₄ |
| Molecular Weight | 5358.06 g/mol |
| CAS Number | 2460055-10-9 |
| Appearance | White to off-white Powder |
| Composition | Lyophilized powder – requires reconstitution |
FOXO4-DRI works by disrupting the interaction between the FOXO4 protein and p53, a key protein involved in regulating the cell cycle and apoptosis (programmed cell death). In senescent cells, FOXO4 binds to p53 to prevent these damaged cells from dying.
The DRI peptide (D-Retro-Inverso) mimics a portion of the FOXO4 protein and acts as a decoy, freeing p53 and allowing it to trigger apoptosis in the senescent cell. This selective removal helps clear out aged or dysfunctional cells without harming healthy ones.
Selective Senescent Cell Removal
FOXO4-DRI has been shown to reduce senescent cell populations in various models, including human chondrocytes, keloid fibroblasts, and aged mice.
Cartilage Regeneration
In autologous chondrocyte implantation (ACI), FOXO4-DRI improved the quality of cartilage by removing senescent cells without harming healthy ones.
Testosterone Restoration
In aged mice, FOXO4-DRI improved testosterone secretion by clearing senescent Leydig cells in the testes.
Anti-Fibrotic and Anti-Tumor Potential
It has shown promise in reducing keloid fibrosis and may help prevent cancer recurrence by eliminating therapy-resistant senescent cells.
Improved Organ Function
By reducing inflammation and cellular waste, it may improve function in organs such as the liver, kidneys, and heart.
Cognitive Support
Clearing senescent cells in the brain could potentially support memory and cognitive health.
Increased Lifespan and Healthspan
In preclinical models, FOXO4-DRI extended healthspan and showed promise in extending lifespan.
All product is sold solely for scientific research purposes. Researchers are responsible for ensuring compliance with local regulations and institutional guidelines. Keep out of reach of children and unauthorized personnel.
1688pharmacy is more than just a trusted supplier of research peptides. We are committed to scientific advancement, dedicated to providing the highest quality pharmaceutical-grade compounds that empower researchers and clients to achieve their goals.
Our proprietary processes and meticulous sourcing of premium materials ensure that every peptide we offer meets the most stringent pharmaceutical standards with verified 99% purity.
Every peptide undergoes rigorous third-party laboratory testing using advanced techniques like HPLC, LC-MS, and NMR. Complete Certificates of Analysis available for transparency and verification.
We provide expedited worldwide shipping with reliable tracking and discreet packaging. Our dedicated customer support team assists with orders, storage guidelines, and product inquiries promptly.