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GH & IGF-1 Secretagogue

This product is intended solely for use as a research chemical in vitro and laboratory experimentation by licensed, qualified professionals.

MK-677 / Ibutamoren : GH & IGF-1 Secretagogue

MK-677 tablets are oral dosage forms of the research chemical Ibutamoren (MK-677)—a non-peptide, ghrelin-receptor agonist classified as a growth-hormone secretagogue that stimulates the body’s release of growth hormone (GH) and insulin-like growth factor-1 (IGF-1).

Specifications Price
10mg × 100 tablets $45.00
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Characteristic Details
Molecular Formula C27H36N4O5S
Molecular Weight 528.66
CAS Number 159634-47-6

Promote the secretion of growth factor-1 (IGF-1) and growth hormone (GH).
Imitate the mechanism of action of ghrelin hormone, combine with the specific ghrelin receptors (GHSR) in the brain, stimulate the production of growth hormone in the brain, increase the level of growth hormone, and not interfere with the normal operation of other hormones in the body (such as cortisol).

↑ GH & IGF-1 levels
Daily 25 mg oral MK-677 restores GH and IGF-1 concentrations to those seen in healthy young adults within 2–4 weeks and sustains them for ≥12 months.
↑ Lean body mass / ↓ fat mass
One-year RCT in 65 elderly adults: +1.1 kg fat-free mass vs ‑0.5 kg with placebo; modest reductions in visceral fat reported in shorter trials.
↑ Bone mineral density (BMD)
12-month data show increased bone-turnover markers; femoral-neck BMD improved when combined with alendronate in post-menopausal women.
Double-blind trials found significant increases in REM and stage-IV sleep duration after 1–2 weeks of 25 mg nightly dosing.
Faster injury recovery
Anecdotal reports and small studies note accelerated healing of tendons, ligaments, and skin, attributed to elevated GH/IGF-1.
Oral convenience
Tablets or liquid taken once daily; avoids injections required for recombinant GH or peptides.
Cost advantage
Reagent-grade MK-677 is markedly cheaper than pharmaceutical-grade GH or GH-releasing peptides.

Water retention & edema can occur due to elevated GH.
Increased appetite is common (ghrelin mimetic effect).
Mild insulin resistance may develop with prolonged use.
Long-term effects are still under study; caution is advised.
Disclaimer:All product is sold solely for scientific research purposes. Researchers are responsible for ensuring compliance with local regulations and institutional guidelines. Keep out of reach of children and unauthorized personnel.

All products are sold solely for scientific research purposes. Researchers are responsible for ensuring compliance with local regulations and institutional guidelines. Keep out of reach of children and unauthorized personnel.

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