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This product is intended solely for use as a research chemical in vitro and laboratory experimentation by licensed, qualified professionals.
Selank is a synthetic peptide developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. It is a heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP) and is a synthetic analog of the immunomodulatory peptide tuftsin. Selank is known for its anxiolytic (anti-anxiety), nootropic (cognitive-enhancing), antidepressant, and immunomodulatory properties.
| 5mg*10vials | $45.00 | $55.00 |
| 10mg*10vials | $90.00 | $100.00 |
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| Molecular Formula | C33H57N11O9 |
|---|---|
| Molecular Weight | 751.87 |
| CAS Number | 129954-34-3 |
| Appearance | White to off-white Powder |
| Composition | Lyophilized powder – requires reconstitution |
Selank primarily works by affecting the GABAergic and monoaminergic systems in the brain. It modulates the levels of:
GABA (gamma-aminobutyric acid) – involved in calming nervous activity
Serotonin – associated with mood regulation
Dopamine – related to motivation and reward
Norepinephrine – linked to alertness and energy
Additionally, Selank may inhibit enzymes like enkephalin-degrading enzymes, which are involved in stress and anxiety responses.
Selank is a multifunctional peptide with significant potential in treating anxiety, depression, and cognitive disorders. Its unique mechanism of action, involving the GABAergic system and neurotrophic factors, makes it a promising candidate for further clinical research and application.
Anxiolytic and Antidepressant Effects
Selank exerts its anxiolytic effects primarily through the GABAergic system, the main inhibitory neurotransmitter system in the brain. It acts as a positive allosteric modulator of GABA receptors, enhancing the inhibitory effects of GABA and thereby reducing anxiety.
Cognitive Enhancement
Selank has been found to improve cognitive functions, including memory and learning processes. It can enhance attention span and overall mental clarity. This nootropic effect is partly due to its ability to increase brain-derived neurotrophic factor (BDNF) levels in the hippocampus, which supports the growth and maintenance of neurons.
Immunomodulatory Activity
Selank mimics many of the effects of tuftsin, including modulating the expression of cytokines such as Interleukin-6 (IL-6) and affecting the balance of T helper cell cytokines. It has been shown to influence the concentration of monoamine neurotransmitters and induce the metabolism of serotonin.
Neuroprotective Effects
Selank has neuroprotective properties, promoting neurogenesis and protecting neurons from damage. It can help in the recovery after neurological events and has been found to elevate the expression of BDNF, which is crucial for neuronal health
Potential Research Applications
Anxiolytic Effects: Reduces anxiety-like behaviors in animal models, comparable to low-dose benzodiazepines but without sedation or cognitive impairment.
Cognitive Enhancement: Improves memory consolidation, attention, and learning processes in rodent studies.
Immunomodulation: Explores effects on immune response under stress, particularly via IL-6 and cytokine modulation.
Neuroprotection: Protects against stress-induced neural damage, potentially relevant for PTSD or chronic stress models.
Substance Withdrawal: Investigates potential to mitigate withdrawal symptoms in models of opioid or alcohol dependency.
Selank is generally well-tolerated, with minimal side effects reported. Possible mild side effects may include:
It is non-toxic, non-addictive, and does not impair motor functions.
All product is sold solely for scientific research purposes. Researchers are responsible for ensuring compliance with local regulations and institutional guidelines. Keep out of reach of children and unauthorized personnel.
1688pharmacy is more than just a trusted supplier of research peptides. We are committed to scientific advancement, dedicated to providing the highest quality pharmaceutical-grade compounds that empower researchers and clients to achieve their goals.
Our proprietary processes and meticulous sourcing of premium materials ensure that every peptide we offer meets the most stringent pharmaceutical standards with verified 99% purity.
Every peptide undergoes rigorous third-party laboratory testing using advanced techniques like HPLC, LC-MS, and NMR. Complete Certificates of Analysis available for transparency and verification.
We provide expedited worldwide shipping with reliable tracking and discreet packaging. Our dedicated customer support team assists with orders, storage guidelines, and product inquiries promptly.